Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Wnt signaling in the intestinal epithelium: from endoderm to cancer Gregorieff A; Clevers HGenes Dev 2005[Apr]; 19 (8): 877-90The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.|Animals[MESH]|Cell Transformation, Neoplastic/*metabolism[MESH]|Colorectal Neoplasms/*genetics/metabolism[MESH]|Cytoskeletal Proteins/metabolism[MESH]|Endoderm/*metabolism[MESH]|Homeostasis/*physiology[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins/genetics/*metabolism[MESH]|Intestinal Mucosa/embryology/*metabolism[MESH]|Mice[MESH]|Mutation/genetics[MESH]|Signal Transduction/*physiology[MESH]|Trans-Activators/metabolism[MESH]|Wnt Proteins[MESH]|beta Catenin[MESH] |