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lüll RNA interference in biology and disease Sledz CA; Williams BRBlood 2005[Aug]; 106 (3): 787-94RNA interference (RNAi) is a conserved biologic response to double-stranded RNA that results in the sequence-specific silencing of target gene expression. Over the past 5 years, an intensive research effort has facilitated the rapid movement of RNAi from a relatively obscure biologic phenomenon to a valuable tool used to silence target gene expression and perform large-scale functional genomic screens. In fact, recent studies reported in this journal and others have demonstrated success using RNAi to address the role of oncogene expression in leukemia cell lines and to validate the therapeutic potential of RNAi for treating these blood disorders. In order to advance these applications and gain an appreciation for the future of RNAi both in basic research and in the treatment of diseases caused by aberrant gene expression, it is important to have an understanding of the process of RNAi and its limitations.|*RNA Interference[MESH]|Gene Expression Regulation, Neoplastic/drug effects[MESH]|Hematologic Neoplasms/therapy[MESH]|Humans[MESH]|RNA, Small Interfering/*therapeutic use[MESH] |