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lüll The search for safer glucocorticoid receptor ligands Rosen J; Miner JNEndocr Rev 2005[May]; 26 (3): 452-64Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity. However, despite their excellent efficacy, severe side effects frequently limit the use of these drugs. The search for novel glucocorticoids with reduced side effects has been intensified by the discovery of new molecular details regarding the function of the glucocorticoid receptor. These new insights may pave the way for novel, safer therapies that retain the efficacy of currently prescribed steroids.|Animals[MESH]|Anti-Inflammatory Agents/adverse effects/*pharmacology/therapeutic use[MESH]|Benzopyrans/adverse effects/*pharmacology/therapeutic use[MESH]|Glucocorticoids/adverse effects/*pharmacology/therapeutic use[MESH]|Humans[MESH]|Inflammation/drug therapy[MESH]|Ligands[MESH]|Quinolines/adverse effects/*pharmacology/therapeutic use[MESH]|Receptors, Glucocorticoid/*metabolism[MESH] |