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Synaptogenesis: a balancing act between excitation and inhibition Cline HCurr Biol 2005[Mar]; 15 (6): R203-5Recent studies have implicated a number of membrane-associated proteins, including the signaling pair neuroligin and beta-neurexin, in synapse formation, suggesting that they govern the ratio of inhibitory and excitatory synapses on CNS neurons. These findings, together with data indicating that the genes encoding neuroligin and PSD95 are altered in autism patients, suggest that a molecular understanding of complex neurological diseases is within reach.|*Signal Transduction[MESH]|Autistic Disorder/*genetics[MESH]|Cell Adhesion Molecules, Neuronal[MESH]|Central Nervous System/*physiology[MESH]|Disks Large Homolog 4 Protein[MESH]|Gene Expression Regulation/*physiology[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins[MESH]|Membrane Proteins/genetics/metabolism[MESH]|Models, Biological[MESH]|Mutation/genetics[MESH]|Nerve Tissue Proteins/genetics/metabolism[MESH]|Neurons/*metabolism[MESH]|Synapses/*metabolism/physiology[MESH] |
