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lüll The roles of receptor and ligand endocytosis in regulating Notch signaling Le Borgne R; Bardin A; Schweisguth FDevelopment 2005[Apr]; 132 (8): 1751-62Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.|*Gene Expression Regulation, Developmental[MESH]|*Models, Biological[MESH]|Animals[MESH]|Cell Communication/*physiology[MESH]|Drosophila Proteins[MESH]|Endocytosis/*physiology[MESH]|Juvenile Hormones/metabolism[MESH]|Ligands[MESH]|Membrane Proteins/metabolism/*physiology[MESH]|Proteins/metabolism[MESH]|Receptors, Notch[MESH]|Signal Transduction/*physiology[MESH]|Ubiquitin/metabolism[MESH]|Wiskott-Aldrich Syndrome Protein[MESH] |