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Myeloperoxidase and cardiovascular disease Nicholls SJ; Hazen SLArterioscler Thromb Vasc Biol 2005[Jun]; 25 (6): 1102-11Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species. In addition to being an integral component of the innate immune response, evidence has emerged that MPO-derived oxidants contribute to tissue damage during inflammation. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation, and acute complication phases of the atherosclerotic process. As a result, MPO and its downstream inflammatory pathways represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.|Cardiovascular Diseases/*immunology/*metabolism/pathology[MESH]|Humans[MESH]|Leukocytes/enzymology[MESH]|Peroxidase/*immunology/metabolism[MESH]|Vasculitis/*immunology/*metabolism/pathology[MESH] |
