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Tendon proteoglycans: biochemistry and function Yoon JH; Halper JJ Musculoskelet Neuronal Interact 2005[Mar]; 5 (1): 22-34Tendon remodeling occurs in response to changes in loading and mobilization. Though the normal mechanical function depends on precise alignment of collagen fibrils, it is proteoglycans that regulate collagen fibrillogenesis and thus, indirectly, tendon function. In this paper we discuss the basic biochemical structure of several members of two proteoglycans families. Decorin, biglycan, fibromodulin and lumican, all members of the small leucine-rich proteoglycans family, bind to collagen fibrils and are active participants in fibrillogenesis. Aggrecan and versican, two members of large modular proteoglycans or lecticans, and their partner hyaluronan likely provide tendon tissues with a high capacity to resist high compressive and tensile forces associated with loading and mobilization. We present data from our laboratory showing that proteoglycans and glycosaminoglycan content increases not only with growth but also with loading of young avian gastrocnemius tendons. Specifically, an increase in the content of keratan sulfate, chondroitin sulfate and hyaluronan was observed. Moderate exercise for several weeks led not only to a further increase in total proteoglycans content but also to qualitative changes in proteoglycan make up.|Adaptation, Physiological/physiology[MESH]|Aging/metabolism[MESH]|Animals[MESH]|Collagen/*metabolism[MESH]|Extracellular Matrix/*chemistry/*metabolism[MESH]|Glycosaminoglycans/chemistry/metabolism[MESH]|Humans[MESH]|Proteoglycans/*chemistry/*metabolism[MESH]|Tendons/*metabolism/ultrastructure[MESH]|Weight-Bearing/physiology[MESH] |
