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SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption McCormick JA; Bhalla V; Pao AC; Pearce DPhysiology (Bethesda) 2005[Apr]; 20 (ä): 134-9Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.|Aldosterone/*metabolism[MESH]|Animals[MESH]|Epithelial Sodium Channels[MESH]|Humans[MESH]|Immediate-Early Proteins[MESH]|Kidney/*metabolism[MESH]|Nuclear Proteins/*metabolism[MESH]|Protein Serine-Threonine Kinases/*metabolism[MESH]|Sodium Channels/metabolism[MESH]|Sodium/*metabolism[MESH] |
