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Systematic review: regression of lymphoproliferative disorders after treatment for hepatitis C infection Gisbert JP; Garcia-Buey L; Pajares JM; Moreno-Otero RAliment Pharmacol Ther 2005[Mar]; 21 (6): 653-62AIM: To systematically review the experience of therapeutic studies where alpha-interferon with or without ribavirin was administered to patients with lymphoproliferative disorders, in order to evaluate whether eradication of hepatitis C virus may induce regression of lymphoproliferative disorders. METHODS: We used bibliographical searches in electronic databases and in the Cochrane Library to determine our results. RESULTS: Sixteen studies where an anti-viral regimen was administered to 65 hepatitis C virus-infected patients with lymphoproliferative disorders were identified. Complete remission of the lymphoproliferative disorder was achieved in 75% of the cases. In contrast, hepatitis C virus-negative subjects did not respond to interferon, indicating that the response in the hepatitis C virus-infected patients is not merely due to the antiproliferative effect of interferon. Remission after HCV eradication was maintained, provided that infection did not reappear. In hepatitis C virus-infected patients with non-Hodgkin's lymphoma treated with corticosteroids/chemotherapy liver function tests deterioration did not occur. The addition of interferon to standard chemotherapy may decrease hepatic side-effects of chemotherapy. CONCLUSIONS: Although it is evident that larger therapeutical trials of anti-viral therapy are needed to determine the role of this strategy in hepatitis C virus-infected patients with lymphoproliferative disorders, encouraging data emerge from recent studies showing that interferon (plus ribavirin) is an attractive therapeutic option for some hepatitis C virus-related low-grade lymphomas.|Antiviral Agents/*therapeutic use[MESH]|Gene Order[MESH]|Genes, bcl-2/genetics[MESH]|Hepatitis C/*drug therapy/genetics[MESH]|Humans[MESH]|Interferon-alpha/*therapeutic use[MESH]|Lymphoproliferative Disorders/*virology[MESH]|Remission Induction[MESH]|Ribavirin/*therapeutic use[MESH] |
