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The RET proto-oncogene: a molecular therapeutic target in thyroid cancer Kodama Y; Asai N; Kawai K; Jijiwa M; Murakumo Y; Ichihara M; Takahashi MCancer Sci 2005[Mar]; 96 (3): 143-8The RET proto-oncogene is responsible for the development of several human inherited and non-inherited diseases. Germline point mutations were identified in multiple endocrine neoplasia types 2A and 2B, and familial medullary thyroid carcinoma. More than 10 rearranged forms of RET, referred to as RET/PTC 1-9, ELKS/RET and RFP/RET, have been cloned from sporadic and radiation-associated papillary thyroid carcinomas. These mutations induced oncogenic activation of RET tyrosine kinase by different mechanisms. To date, various kinds of therapeutic approaches have been developed for the treatment of RET-associated cancers, including tyrosine kinase inhibitors, gene therapy with dominant negative RET mutants, and RNA interference to abrogate oncogenic mutant RET expression. RET and some signaling molecules that function downstream of RET could be potential targets for the development of selective cancer therapeutics.|*RNA Interference[MESH]|Antineoplastic Agents/pharmacology[MESH]|Enzyme Inhibitors/pharmacology[MESH]|Germ-Line Mutation[MESH]|Humans[MESH]|Neoplasms/*drug therapy/genetics/physiopathology[MESH]|Oncogene Proteins/biosynthesis/*genetics[MESH]|Protein-Tyrosine Kinases/*antagonists & inhibitors/pharmacology[MESH]|Proto-Oncogene Mas[MESH]|Proto-Oncogene Proteins c-ret[MESH]|Receptor Protein-Tyrosine Kinases/biosynthesis/*genetics[MESH]|Signal Transduction[MESH] |
