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lüll Oxygen, oxidative stress, hypoxia, and heart failure Giordano FJJ Clin Invest 2005[Mar]; 115 (3): 500-8A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.|*Oxidative Stress[MESH]|Animals[MESH]|Calcium/metabolism[MESH]|Cardiac Output, Low/pathology/*physiopathology[MESH]|Energy Metabolism[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Hypertrophy[MESH]|Hypoxia/*metabolism[MESH]|Ion Channels/metabolism[MESH]|Lipids/toxicity[MESH]|Mitochondria/metabolism[MESH]|Myocardial Ischemia/metabolism[MESH]|Myocardium/cytology/metabolism/pathology[MESH]|Oxygen/*metabolism[MESH]|Reactive Oxygen Species/metabolism[MESH]|Signal Transduction/physiology[MESH] |