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lüll Learning from failure: congestive heart failure in the postgenomic age Benjamin IJ; Schneider MDJ Clin Invest 2005[Mar]; 115 (3): 495-9The prognosis of heart failure is worse than that of most cancers, but new therapeutic interventions using stem and other cell-based therapies are succeeding in the fight against it, and old drugs, with new twists, are making a comeback. Genetically engineered animal models are driving insights into the molecular mechanisms that cause hearts to fail, accelerating drug discoveries, and inspiring cell-based therapeutic interventions for both acquired and inheritable cardiac diseases.|*Genomics[MESH]|*Heart Failure/genetics/physiopathology/therapy[MESH]|Animals[MESH]|Animals, Genetically Modified[MESH]|Apoptosis/physiology[MESH]|Calcium/metabolism[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Mitochondria/metabolism[MESH]|Nitric Oxide/metabolism[MESH]|Oxidative Stress[MESH]|Protein Kinases/metabolism[MESH]|Signal Transduction/physiology[MESH]|Transcription, Genetic[MESH] |