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Quorum sensing and quorum-quenching enzymes Dong YH; Zhang LHJ Microbiol 2005[Feb]; 43 Spec No (ä): 101-9To gain maximal benefit in a competitive environment, single-celled bacteria have adopted a community genetic regulatory mechanism, known as quorum sensing (QS). Many bacteria use QS signaling systems to synchronize target gene expression and coordinate biological activities among a local population. N-acylhomoserine lactones (AHLs) are one family of the well-characterized QS signals in Gram-negative bacteria, which regulate a range of important biological functions, including virulence and biofilm formation. Several groups of AHL-degradation enzymes have recently been identified in a range of living organisms, including bacteria and eukaryotes. Expression of these enzymes in AHL-dependent pathogens and transgenic plants efficiently quenches the microbial QS signaling and blocks pathogenic infections. Discovery of these novel quorum quenching enzymes has not only provided a promising means to control bacterial infections, but also presents new challenges to investigate their roles in host organisms and their potential impacts on ecosystems.|*Gene Expression Regulation, Developmental[MESH]|4-Butyrolactone/*analogs & derivatives/*metabolism[MESH]|Aminohydrolases/*metabolism[MESH]|Animals[MESH]|Bacteria/*enzymology/growth & development[MESH]|Carboxylic Ester Hydrolases/*metabolism[MESH]|Eukaryotic Cells/*enzymology/physiology[MESH]|Humans[MESH]|Signal Transduction[MESH] |
