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Proteomic applications of surface plasmon resonance biosensors: analysis of protein arrays Yuk JS; Ha KSExp Mol Med 2005[Feb]; 37 (1): 1-10Proteomics is one of the most important issues in the post-genomic area, because it can greatly contribute to identifying protein biomarkers for disease diagnosis and drug screening. Protein array is a key technology for proteome researches and has been analyzed by various methods including fluorescence, mass spectrometry, atomic force microscopy and surface plasmon resonance (SPR). SPR biosensor is a promising technology in proteomics, since it has various advantages including real-time measurement of biomolecular interactions without labeling and the simple optical system for the device. SPR biosensors have a strong potential for analyzing proteomes by SPR imaging and SPR spectroscopic imaging, even though the challenge is to produce proteins on a proteomic scale.|*Biosensing Techniques[MESH]|*Proteomics[MESH]|*Surface Plasmon Resonance/instrumentation/methods[MESH]|Animals[MESH]|Humans[MESH]|Protein Array Analysis[MESH] |
