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lüll Natural killer cells and reproductive failure--theory, practice and prejudice Rai R; Sacks G; Trew GHum Reprod 2005[May]; 20 (5): 1123-6The relationship between peripheral blood natural killer (NK) cells and reproductive failure is one of the most controversial areas in reproductive medicine. Amidst much publicity, peripheral blood NK cell testing is being promoted as a useful diagnostic test to guide the initiation of a variety of immunosuppressive therapies amongst patients with either recurrent miscarriage or infertility. We contend (i) that at present there is no scientific basis for the introduction of NK cell testing into routine clinical practice, and (ii) that the use of immunosuppressant agents based on the results of such testing may potentially be harmful.|*Reproductive Techniques, Assisted[MESH]|Abortion, Habitual/blood[MESH]|Blood Cell Count[MESH]|Female[MESH]|Humans[MESH]|Immunosuppressive Agents/adverse effects/*therapeutic use[MESH]|Infertility, Female/*blood/*therapy[MESH]|Killer Cells, Natural/drug effects/*physiology[MESH]|Pregnancy[MESH]|Treatment Outcome[MESH] |