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lüll Exiting the endoplasmic reticulum Mancias JD; Goldberg JTraffic 2005[Apr]; 6 (4): 278-85Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the initial step in protein secretion. COPII-coated vesicles mediate the export of newly synthesized proteins from the ER, and this transport step is coupled with COPI-mediated retrograde traffic to form a transport circuit that supports the compositional asymmetry of the ER-Golgi system. Biochemical and structural studies have advanced our understanding of the mechanisms that control vesicle formation and cargo-protein capture. Recent work has highlighted the function of transitional ER regions in specifying the location of COPII budding.|Animals[MESH]|COP-Coated Vesicles/chemistry/genetics/metabolism[MESH]|Cell Membrane/chemistry/genetics/metabolism[MESH]|Endoplasmic Reticulum/chemistry/*metabolism[MESH]|Protein Transport[MESH] |