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First-trimester screening: an overview Eiben B; Glaubitz RJ Histochem Cytochem 2005[Mar]; 53 (3): 281-3An improvement in prenatal screening for chromosomal defects has been achieved by combining sonography and biochemical markers. Analyzing markers taken from maternal blood such as pregnancy-associated plasma protein A and free beta-human chorionic gonadotropin in combination with the ultrasound marker nuchal translucency provides detection rates of 90% for the most important chromosomal anomalies. In addition, nuchal translucency is a marker for severe heart defects. This report discusses the potential of new markers such as the nasal bone.|*Chromosome Aberrations[MESH]|Age Factors[MESH]|Biomarkers/blood[MESH]|Chorionic Gonadotropin, beta Subunit, Human/blood[MESH]|Down Syndrome/diagnosis[MESH]|Female[MESH]|Humans[MESH]|Nasal Bone/diagnostic imaging/embryology[MESH]|Nuchal Translucency Measurement[MESH]|Pregnancy[MESH]|Pregnancy Trimester, First[MESH]|Pregnancy-Associated Plasma Protein-A/analysis[MESH]|Prenatal Diagnosis/*methods[MESH]|Ultrasonography, Prenatal[MESH] |
