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ISCOM-based vaccines: the second decade Sanders MT; Brown LE; Deliyannis G; Pearse MJImmunol Cell Biol 2005[Apr]; 83 (2): 119-28The immunostimulating complex or 'iscom' was first described 20 years ago as an antigen delivery system with powerful immunostimulating activity. Iscoms are cage-like structures, typically 40 nm in diameter, that are comprised of antigen, cholesterol, phospholipid and saponin. ISCOM-based vaccines have been shown to promote both antibody and cellular immune responses in a variety of experimental animal models. This review focuses on the evaluation of ISCOM-based vaccines in animals over the past 10 years, as well as examining the progress that has been achieved in the development of human vaccines based on ISCOM adjuvant technology.|Animals[MESH]|Antigens/administration & dosage[MESH]|CD8-Positive T-Lymphocytes/immunology[MESH]|Cholesterol/immunology[MESH]|Drug Combinations[MESH]|Drug Delivery Systems[MESH]|Humans[MESH]|ISCOMs/*immunology[MESH]|Immune System/immunology[MESH]|Mice[MESH]|Microscopy, Electron[MESH]|Phospholipids/immunology[MESH]|Saponins/immunology[MESH] |
