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Transglutaminase function in epidermis Eckert RL; Sturniolo MT; Broome AM; Ruse M; Rorke EAJ Invest Dermatol 2005[Mar]; 124 (3): 481-92Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.|Epidermal Cells[MESH]|Epidermis/*enzymology[MESH]|Humans[MESH]|Keratinocytes/cytology/*enzymology[MESH]|Transglutaminases/*physiology[MESH] |
