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  • CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2
  • Antony PA; Restifo NP
  • J Immunother 2005[Mar]; 28 (2): 120-8
  • CD4+CD25+ T regulatory (Treg) cells control immunologic tolerance to self-antigens and play a role in suppressing antitumor immune responses, but the mechanism of suppression in vivo remains uncertain. Recently, signaling through the high-affinity interleukin-2 (IL-2) receptor has been shown to be critical for Treg cell differentiation and survival in vivo. Mice deficient in IL-2 or its receptor (CD25 or CD122) or deficient in downstream signaling molecules, including JAK-3 and STAT-5, do not develop a stable population of Treg cells and subsequently acquire lymphoproliferative disease and autoimmunity. in vitro, IL-2 is required to expand Treg cells and to induce their suppressive characteristics. Conversely, IL-2-based regimens can activate cellular antitumor immunity and are the mainstay of immunotherapies directed against melanoma and kidney cancers. Given the seemingly disparate effects of IL-2, the authors discuss the possibility that IL-2 may not be the optimal T-cell growth factor in vivo, but rather an inducer of self-tolerance. The authors propose that other gamma c-signaling cytokines, including IL-15, may be alternative choices for the immunotherapy of cancer.
  • |Adoptive Transfer[MESH]
  • |Animals[MESH]
  • |Binding Sites[MESH]
  • |Bone Marrow Cells/metabolism[MESH]
  • |CD4-Positive T-Lymphocytes/cytology/*immunology[MESH]
  • |Dendritic Cells/cytology[MESH]
  • |Humans[MESH]
  • |Immunotherapy/*methods[MESH]
  • |Interleukin-2/metabolism/*physiology[MESH]
  • |Lymphoproliferative Disorders/therapy[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Models, Biological[MESH]
  • |Neoplasms/metabolism/*therapy[MESH]
  • |Phenotype[MESH]
  • |Receptors, Interleukin-2/*biosynthesis[MESH]
  • |T-Lymphocytes/metabolism[MESH]

  • *{{pmid15725955}}
    *<b>[ CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2 ]</b> J Immunother 2005; 28(2) ; 120-8 Antony PA; Restifo NP


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    J Immunother

    120 2.28 2005