Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Estrogen receptor-related receptor alpha: a mediator of estrogen response in bone Bonnelye E; Aubin JEJ Clin Endocrinol Metab 2005[May]; 90 (5): 3115-21Estrogen receptor-related receptor-alpha (ERRalpha) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERalpha/beta, but it does not bind estrogen. However, several recent studies suggest that ERRalpha not only plays a functional role in osteoblasts but also impinges on the estrogen axis in bone, as it does in at least certain other estrogen target tissues. We summarize here data on ERRalpha and its cellular and molecular modes of action that have broad implications for considering the potential role of this orphan receptor as a new therapeutic target in osteopenic disorders such as osteoporosis as well as other estrogen-responsive conditions.|Aromatase/genetics[MESH]|Bone and Bones/*drug effects/physiology[MESH]|ERRalpha Estrogen-Related Receptor[MESH]|Estrogens/*pharmacology[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Nitric Oxide Synthase Type III[MESH]|Nitric Oxide Synthase/genetics[MESH]|Osteogenesis[MESH]|Receptors, Cytoplasmic and Nuclear/*physiology[MESH]|Receptors, Estrogen/*physiology[MESH] |