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Review article: monitoring of immunomodulators in inflammatory bowel disease Aberra FN; Lichtenstein GRAliment Pharmacol Ther 2005[Feb]; 21 (4): 307-19The armamentarium of medications for the treatment of inflammatory bowel disease is growing and becoming more complicated to use. Immunomodulators are a class of medications that have found a niche for the treatment of Crohn's disease and ulcerative colitis. Because of the mounting supporting evidence for efficacy, the most commonly-used immunomodulators are azathioprine, mercaptopurine, methotrexate and ciclosporin. These medications are being used more often due to their steroid-sparing and potentially surgery-sparing effects. Immunomodulators are also known for a significant side-effect profile and require careful monitoring. This review provides the latest information for clinicians on efficacy, side-effects, dosing and monitoring of these medications for treatment of inflammatory bowel disease.|Azathioprine/therapeutic use[MESH]|Cyclosporine/therapeutic use[MESH]|Drug Monitoring/*methods[MESH]|Humans[MESH]|Immunosuppressive Agents/*therapeutic use[MESH]|Inflammatory Bowel Diseases/*drug therapy[MESH]|Mercaptopurine/therapeutic use[MESH]|Methotrexate/therapeutic use[MESH] |
