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HGF/SF-Met signaling in tumor progression Gao CF; Vande Woude GFCell Res 2005[Jan]; 15 (1): 49-51Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.|*Disease Progression[MESH]|*Signal Transduction[MESH]|Adaptor Proteins, Signal Transducing/metabolism[MESH]|Animals[MESH]|Cell Proliferation[MESH]|GRB2 Adaptor Protein[MESH]|Hepatocyte Growth Factor/*metabolism[MESH]|Humans[MESH]|Inositol Polyphosphate 5-Phosphatases[MESH]|Models, Biological[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/metabolism/*pathology[MESH]|Neovascularization, Pathologic[MESH]|Phenotype[MESH]|Phosphoric Monoester Hydrolases/metabolism[MESH]|Proto-Oncogene Proteins c-cbl[MESH]|Proto-Oncogene Proteins c-met/*metabolism[MESH]|Proto-Oncogene Proteins/metabolism[MESH]|Ubiquitin-Protein Ligases/metabolism[MESH]|ras Proteins/metabolism[MESH] |