Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein Trakul N; Rosner MRCell Res 2005[Jan]; 15 (1): 19-23Proteins like Raf kinase inhibitory protein (RKIP) that serve as modulators of signaling pathways, either by promoting or inhibiting the formation of productive signaling complexes through protein-protein interactions, have been demonstrated to play an increasingly important role in a number of cell types and organisms. These proteins have been implicated in development as well as the progression of cancer. RKIP is a particularly interesting regulator, as it is a highly conserved, ubiquitously expressed protein that has been shown to play a role in growth and differentiation in a number of organisms and can regulate multiple signaling pathways. RKIP is also the first MAP kinase signaling modulator to be identified as playing a role in cancer metastasis, and identification of the mechanism by which it regulates Raf-1 activation provides new targets for therapeutic intervention.|*MAP Kinase Signaling System[MESH]|Animals[MESH]|Cattle[MESH]|Cell Differentiation[MESH]|Cell Proliferation[MESH]|Disease Progression[MESH]|Humans[MESH]|Mice[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/metabolism/pathology[MESH]|Neurons/metabolism[MESH]|Protein Kinase C/metabolism[MESH]|Rats[MESH]|Signal Transduction[MESH]|raf Kinases/*metabolism[MESH] |
