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lüll Alternative treatments for Clostridium difficile disease: what really works?McFarland LVJ Med Microbiol 2005[Feb]; 54 (Pt 2): 101-111Vancomycin and metronidazole have been used for treating Clostridium difficile-associated disease (CDAD) for the past 25 years, but approximately 20 % of patients develop recurrent disease. The increasing incidence of nosocomial outbreaks, cases of recurrent CDAD and other complications (toxic megacolon, ileus, sepsis) has fuelled the search for different types of treatments. As the understanding of the pathogenesis of this disease has matured, newer treatment strategies that take advantage of these mechanisms have been developed. This review will describe such treatments and examine the evidence for each strategy.|*Clostridioides difficile/isolation & purification[MESH]|*Complementary Therapies[MESH]|Anti-Infective Agents/*therapeutic use[MESH]|Carrier State/*drug therapy[MESH]|Clostridium Infections/*drug therapy/epidemiology[MESH]|Colitis/microbiology/prevention & control[MESH]|Cross Infection/microbiology/prevention & control[MESH]|Humans[MESH]|Metronidazole/therapeutic use[MESH]|Vancomycin/therapeutic use[MESH] |