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Porocytosis: a transient pore array secretes the neurotransmitter packet Kriebel ME; Keller B; Silver RB; Pappas GDAnat Rec B New Anat 2005[Jan]; 282 (1): 38-41The porocytosis hypothesis is based on the arrayed nature of synaptic vesicles which forms the anatomical functional unit of secretion. The presynaptic array and the postsynaptic array of receptors form a synaptomere which is the unit of transmission. A transient increase in calcium ions, triggered by an action potential, activates all pores of the array to pulse transmitter. The array insures transmission while permitting a frequency dependent amount of secretion. Therefore the amount of secretion is variable which permits plasticity. Secretion from the array has the property of immediate synaptic plasticity whereas a change in array size would change synaptic strength. The robust nature of the array insures fidelity of transmission, a frequency dependent dynamic signature of transmission giving the property of immediate plasticity; and, a change in array size yields a change in synaptic strength for long term reliability.|Animals[MESH]|Calcium/*metabolism[MESH]|Exocytosis/physiology[MESH]|Humans[MESH]|Membrane Fusion/physiology[MESH]|Neuronal Plasticity[MESH]|Neurotransmitter Agents/*metabolism[MESH]|Presynaptic Terminals/*metabolism[MESH]|Synaptic Transmission[MESH]|Synaptic Vesicles/*physiology[MESH] |
