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lüll Protein structural transitions and their functional role Karplus M; Gao YQ; Ma J; van der Vaart A; Yang WPhilos Trans A Math Phys Eng Sci 2005[Feb]; 363 (1827): 331-55; discussion 355-6Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli, which aids in protein folding; the other is F(1)-ATPase, a motor protein which synthesizes and hydrolyses ATP.|*Models, Biological[MESH]|*Models, Molecular[MESH]|Chaperonin 60/*chemistry/*metabolism[MESH]|Energy Transfer/*physiology[MESH]|Models, Chemical[MESH]|Molecular Motor Proteins/chemistry/physiology[MESH]|Motion[MESH]|Protein Conformation[MESH]|Protein Folding[MESH]|Proton-Translocating ATPases/*chemistry/*metabolism[MESH]|Structure-Activity Relationship[MESH] |