Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels Gu Q; Lin RL; Hu HZ; Zhu MX; Lee LYAm J Physiol Lung Cell Mol Physiol 2005[May]; 288 (5): L932-41This study was carried out to determine the effect of 2-aminoethoxydiphenyl borate (2-APB), a common activator of transient receptor potential vanilloid (TRPV) type 1, 2, and 3 channels, on cardiorespiratory reflexes, pulmonary C fiber afferents, and isolated pulmonary capsaicin-sensitive neurons. In anesthetized, spontaneously breathing rats, intravenous bolus injection of 2-APB elicited the pulmonary chemoreflex responses, characterized by apnea, bradycardia, and hypotension. After perineural treatment of both cervical vagi with capsaicin to block the conduction of C fibers, 2-APB no longer evoked any of these reflex responses. In open-chest and artificially ventilated rats, 2-APB evoked an abrupt and intense discharge in vagal pulmonary C fibers in a dose-dependent manner. The stimulation of C fibers by 2-APB was attenuated but not abolished by capsazepine, a selective antagonist of the TRPV1, which completely blocked the response to capsaicin in these C fiber afferents. In isolated pulmonary capsaicin-sensitive neurons, 2-APB concentration dependently evoked an inward current that was partially inhibited by capsazepine but almost completely abolished by ruthenium red, an effective blocker of all TRPV channels. In conclusion, 2-APB evokes a consistent and distinct stimulatory effect on pulmonary C fibers in vivo and on isolated pulmonary capsaicin-sensitive neurons in vitro. These results establish the functional evidence demonstrating that TRPV1, V2, and V3 channels are expressed on these sensory neurons and their terminals.|Animals[MESH]|Blood Pressure/drug effects[MESH]|Boron Compounds/*pharmacology[MESH]|Capsaicin/*analogs & derivatives/pharmacology[MESH]|Cation Transport Proteins/physiology[MESH]|Coloring Agents/pharmacology[MESH]|Heart Rate/drug effects[MESH]|Ion Channels/*physiology[MESH]|Lung/*innervation[MESH]|Nerve Fibers, Unmyelinated/*drug effects/*physiology[MESH]|Nodose Ganglion/cytology[MESH]|Rats[MESH]|Rats, Sprague-Dawley[MESH]|Receptors, Drug/physiology[MESH]|Reflex/drug effects[MESH]|Respiratory Mechanics/drug effects[MESH]|Ruthenium Red/pharmacology[MESH]|TRPV Cation Channels[MESH] |