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Caenorhabditis elegans as a model to study renal development and disease: sexy cilia Barr MMJ Am Soc Nephrol 2005[Feb]; 16 (2): 305-12The nematode Caenorhabditis elegans has no kidney per se, yet "the worm" has proved to be an excellent model to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport and ion channel function, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD). The goal of this review is to explain how C. elegans has provided insight into cilia development, cilia function, and human cystic kidney diseases.|*Gene Expression Regulation, Developmental[MESH]|*Genetic Predisposition to Disease[MESH]|Animals[MESH]|Caenorhabditis elegans Proteins/*genetics[MESH]|Caenorhabditis elegans/*embryology/genetics[MESH]|Cilia/genetics[MESH]|Disease Models, Animal[MESH]|Female[MESH]|Helminth Proteins/genetics[MESH]|Humans[MESH]|Male[MESH]|Models, Animal[MESH]|Mutation[MESH]|Organogenesis/genetics/*physiology[MESH]|Polycystic Kidney, Autosomal Dominant/genetics[MESH]|Polycystic Kidney, Autosomal Recessive/genetics[MESH]|Species Specificity[MESH] |
