suck pdf from google scholar
PDF vom PMID15639804  :  Publisher
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text


  • DeepDyve
  • Pubget Overpricing


  • lüll
  • The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer s disease
  • Tsai VW; Scott HL; Lewis RJ; Dodd PR
  • Neurotox Res 2005[]; 7 (1-2): 125-41
  • Neurodegenerative diseases such as Huntington's disease, ischemia, and Alzheimer's disease (AD) are major causes of death. Recently, metabotropic glutamate receptors (mGluRs), a group of seven-transmembrane-domain proteins that couple to G-proteins, have become of interest for studies of pathogenesis. Group I mGluRs control the levels of second messengers such as inositol 1,4,5-triphosphate (IP3), Ca2+ ions and cAMP. They elicit the release of arachidonic acid via intracellular Ca2+ mobilization from intracellular stores such as mitochondria and endoplasmic reticulum. This facilitates the release of glutamate and could trigger the formation of neurofibrillary tangles, a pathological hallmark of AD. mGluRs regulate neuronal injury and survival, possibly through a series of downstream protein kinase and cysteine protease signaling pathways that affect mitochondrially mediated programmed cell death. They may also play a role in glutamate-induced neuronal death by facilitating Ca(II) mobilization. Hence, mGluRs have become a target for neuroprotective drug development. They represent a pharmacological path to a relatively subtle amelioration of neurotoxicity because they serve a modulatory rather than a direct role in excitatory glutamatergic transmission.
  • |Alzheimer Disease/*metabolism[MESH]
  • |Animals[MESH]
  • |Excitatory Amino Acid Agents/metabolism/*toxicity[MESH]
  • |Humans[MESH]
  • |Neurons/drug effects/*pathology[MESH]
  • |Receptors, Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology[MESH]





  • *{{pmid15639804}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=15639804 The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer s disease ]</b> Neurotox Res 2005; 7(1-2) ; 125-41 Tsai VW; Scott HL; Lewis RJ; Dodd PR

        *15639804*

    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Neurotox Res

    125 1-2.7 2005