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lüll Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines Gurbuz AT; Elliott WG; Zia AAEur J Cardiothorac Surg 2005[Jan]; 27 (1): 138-49Heparin-induced thrombocytopenia/thrombosis is an immunologic reaction to unfractionated heparin characterized by thrombocytopenia, platelet activation and thrombosis. A high index of suspicion is required for timely diagnosis and treatment. Treatment is complex and outcome maybe less then satisfactory.|Ancrod/therapeutic use[MESH]|Antibodies/analysis[MESH]|Anticoagulants/*therapeutic use[MESH]|Arginine/analogs & derivatives[MESH]|Cardiovascular Diseases/complications/surgery[MESH]|Chondroitin Sulfates/therapeutic use[MESH]|Dermatan Sulfate/therapeutic use[MESH]|Fibrinolytic Agents/*adverse effects[MESH]|Heparin, Low-Molecular-Weight/therapeutic use[MESH]|Heparin/*adverse effects[MESH]|Heparitin Sulfate/therapeutic use[MESH]|Hirudin Therapy/methods[MESH]|Hirudins/*analogs & derivatives[MESH]|Humans[MESH]|Peptide Fragments/therapeutic use[MESH]|Pipecolic Acids/therapeutic use[MESH]|Practice Guidelines as Topic[MESH]|Purpura, Thrombocytopenic, Idiopathic/*chemically induced/diagnosis/drug therapy[MESH]|Recombinant Proteins/therapeutic use[MESH]|Sulfonamides[MESH]|Thrombin/antagonists & inhibitors[MESH] |