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Neuro-ophthalmological findings in sarcoidosis Heuser K; Kerty EActa Ophthalmol Scand 2004[Dec]; 82 (6): 723-9PURPOSE: This review emphasizes the importance of neuro-ophthalmological signs and symptoms in sarcoidosis. The presence of ophthalmological and neuro-ophthalmological findings may lead to diagnosis of the disease and the initiation of adequate treatment. MATERIAL AND METHODS: Patients who had been diagnosed with neurosarcoidosis during the period 1990 - 2001 were identified from the departmental diagnostic index. The history, clinical, laboratory and imaging data of patients were analysed. RESULTS: Fifteen patients were identified, four men and 11 women, with a mean age of 44.1 years (range 26-65 years). In six of the 15 (40%), neurological deficits were the initial symptoms. Nine (60%) had known sarcoidosis at the time of presentation. Ten patients (66%) had ophthalmological/neuro-ophthalmological symptoms and signs. CONCLUSION: Neuro-ophthalmological symptoms may develop early in neurosarcoidosis. If neuro-ophthalmological symptoms arise in patients with established biopsy-proven sarcoidosis, the diagnosis is usually easy to make. However, a number of patients with neurosarcoidosis may present with neuro-ophthalmic symptoms before systemic involvement becomes obvious. In this situation the diagnosis is challenging, and the major goal is to establish the presence of systemic sarcoidosis.|Adult[MESH]|Aged[MESH]|Cranial Nerve Diseases/*diagnosis/drug therapy[MESH]|Electromyography[MESH]|European Union[MESH]|Eye Diseases/*diagnosis/drug therapy[MESH]|Female[MESH]|Glucocorticoids/therapeutic use[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Middle Aged[MESH]|Oculomotor Nerve Diseases/diagnosis/drug therapy[MESH]|Ophthalmoplegia/diagnosis/drug therapy[MESH]|Prednisone/therapeutic use[MESH]|Radiography, Thoracic[MESH]|Retrospective Studies[MESH]|Sarcoidosis/*diagnosis/drug therapy[MESH]|Tomography, Emission-Computed, Single-Photon[MESH]|Tonic Pupil/diagnosis/drug therapy[MESH] |
