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Platelets and metastasis revisited: a novel fatty link Gupta GP; Massague JJ Clin Invest 2004[Dec]; 114 (12): 1691-3Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis.|*Neoplasm Metastasis[MESH]|Blood Platelets/*metabolism/*physiology[MESH]|Bone and Bones/pathology[MESH]|Breast Neoplasms/metabolism[MESH]|Cell Line, Tumor[MESH]|Disease Progression[MESH]|Female[MESH]|Humans[MESH]|Lysophospholipids/*metabolism[MESH]|Models, Biological[MESH]|Neovascularization, Pathologic[MESH]|Osteolysis[MESH]|Ovarian Neoplasms/metabolism[MESH] |
