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lüll Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal degeneration Josephs KA; Tang-Wai DF; Edland SD; Knopman DS; Dickson DW; Parisi JE; Petersen RC; Jack CR Jr; Boeve BFArch Neurol 2004[Dec]; 61 (12): 1881-4BACKGROUND: Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS. OBJECTIVE: To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD. DESIGN: Historical review of autopsy cases. SETTING: Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center. PATIENTS: Seventeen patients with CBS who had an autopsy-confirmed diagnosis of CBD or another neurodegenerative disease. MAIN OUTCOME MEASURES: Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes. RESULTS: Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases. CONCLUSION: Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.|Aged[MESH]|Atrophy/pathology[MESH]|Cerebral Cortex/*pathology[MESH]|Corpus Callosum/*pathology[MESH]|Female[MESH]|Humans[MESH]|Magnetic Resonance Imaging/*methods[MESH]|Male[MESH]|Middle Aged[MESH]|Neurodegenerative Diseases/*pathology[MESH]|Statistics, Nonparametric[MESH] |