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lüll Hypoxic pulmonary vasoconstriction: role of ion channels Mauban JR; Remillard CV; Yuan JXJ Appl Physiol (1985) 2005[Jan]; 98 (1): 415-20Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia causes structural changes of the pulmonary vasculature including arterial medial hypertrophy. Electro- and pharmacomechanical mechanisms are involved in regulating pulmonary vasomotor tone, whereas intracellular Ca(2+) serves as an important signal in regulating contraction and proliferation of pulmonary artery smooth muscle cells. Herein, we provide a basic overview of the cellular mechanisms involved in the development of hypoxic pulmonary vasoconstriction. Our discussion focuses on the roles of ion channels permeable to K(+) and Ca(2+), membrane potential, and cytoplasmic Ca(2+) in the development of acute hypoxic pulmonary vasoconstriction and chronic hypoxia-mediated pulmonary vascular remodeling.|*Ion Channel Gating[MESH]|*Vasoconstriction[MESH]|Animals[MESH]|Calcium/*metabolism[MESH]|Hemostasis[MESH]|Humans[MESH]|Hypertension, Pulmonary/etiology/*physiopathology[MESH]|Hypoxia/complications/*physiopathology[MESH]|Ion Channels/*metabolism[MESH]|Lung/blood supply/physiopathology[MESH]|Models, Biological[MESH]|Oxygen/metabolism[MESH]|Pulmonary Artery/*physiopathology[MESH] |