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lüll Regulation of immunity by lysosphingolipids and their G protein-coupled receptors Goetzl EJ; Rosen HJ Clin Invest 2004[Dec]; 114 (11): 1531-7T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graft rejection in humans and autoimmunity in animal models without apparent impairment of host defenses against infections suggests that this system is a promising target for new forms of immunotherapy.|Animals[MESH]|B-Lymphocytes/immunology/physiology[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Immunity/*physiology[MESH]|Receptors, G-Protein-Coupled/*immunology[MESH]|Receptors, Lysosphingolipid/immunology[MESH]|Sphingolipids/*immunology[MESH]|T-Lymphocytes/immunology/physiology[MESH] |