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Review article: orofacial granulomatosis Leao JC; Hodgson T; Scully C; Porter SAliment Pharmacol Ther 2004[Nov]; 20 (10): 1019-27Orofacial granulomatosis is an uncommon clinicopathological entity describing patients who have oral lesions characterized by persistent and/or recurrent labial enlargement, oral ulcers and a variety of other orofacial features, who on lesional biopsy have lymphoedema and non-caseating granulomas. The aetiology of oral lesions with non-caseating granulomas includes oral Crohn's disease (some patients with oral lesions will develop typical bowel symptoms of Crohn's disease in ensuing months to years), tooth-associated infections, sarcoidosis and food or contact allergies. Treatment of orofacial granulomatosis is not reliably effective and may not be always necessary, although most patients do require some medical intervention.|Diagnosis, Differential[MESH]|Facial Dermatoses/etiology/*pathology/therapy[MESH]|Granuloma/etiology/*pathology/therapy[MESH]|Humans[MESH]|Mouth Diseases/etiology/*pathology/therapy[MESH]|Recurrence[MESH] |
