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lüll Biosynthesis of pantothenate Webb ME; Smith AG; Abell CNat Prod Rep 2004[Dec]; 21 (6): 695-721Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria and plants is discussed in detail. In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of pantothenate are included.|Amino Acid Sequence[MESH]|Arabidopsis/enzymology/genetics/metabolism[MESH]|Bacteria/enzymology/genetics/metabolism[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Pantothenic Acid/*biosynthesis[MESH]|Peptide Synthases/*metabolism[MESH]|Saccharomyces cerevisiae/enzymology/genetics/metabolism[MESH]|Sequence Analysis, Protein[MESH] |