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Anti-laminin-1 autoantibodies, pregnancy loss and endometriosis Inagaki J; Kondo A; Lopez LR; Shoenfeld Y; Matsuura EClin Dev Immunol 2004[Sep]; 11 (3-4): 261-6Laminin-1 is a major component and multifunctional glycoprotein of basement membranes that consists of three different subunits, alpha1, beta1 and gamma11 chains. It is the earliest synthesized network-forming protein during embryogenesis and plays an important role in embryonic development, embryonic implantation and placentation. We have recently shown that IgG anti-laminin-1 antibodies were significantly associated with recurrent first-trimester miscarriages and with subsequent pregnancy outcome. Interestingly, these antibodies were also observed in patients with endometriosis-associated infertility but not in patients with other causes of infertility, including tubal factors, hormonal and uterine abnormalities. Laminin-alpha1, -beta1 and -gamma1 mRNAs have been detected in 90% of endometriotic lesions and all laminin-alpha1, -beta1 and -gamma1 chains were localized in the basement membranes of glandular epithelium in endometriotic peritoneal lesions. Western blot analysis showed that anti-laminin-1 antibodies from those patients reacted with all laminin-1's chains. ELISA also confirmed that one of the target epitopes for these antibodies was located in a particular region of the laminin-1 molecule, i.e. the carboxyl-terminal globular G domain of alpha1 chain. IgM monoclonal anti-laminin-1 autoantibody, that we recently established, also recognized the G domain. Anti-laminin-1 antibodies from mice immunized with "mouse" laminin-1, caused a higher fetal resorption rate with lower embryonic and placental weights. Thus, anti-laminin-1 antibodies may be important in development of autoimmune-mediated reproductive failures and the assessment of the antibodies may provide a novel non-invasive diagnosis of endometriosis.|Abortion, Habitual/*immunology[MESH]|Adult[MESH]|Animals[MESH]|Autoantibodies/*metabolism[MESH]|Endometriosis/complications/*immunology[MESH]|Female[MESH]|Humans[MESH]|Immunoglobulin G/metabolism[MESH]|Immunoglobulin M/metabolism[MESH]|Infertility, Female/etiology/immunology[MESH]|Laminin/chemistry/*immunology[MESH]|Models, Molecular[MESH]|Pregnancy[MESH]|Protein Subunits[MESH] |
