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Making the right choice--long-range chromosomal interactions in development Broach JRCell 2004[Nov]; 119 (5): 583-6Schizosaccharomyces pombe has the remarkable potential to switch mating type as often as every generation, through selective interaction of an expressor locus with either of two transcriptionally silent donor loci. Recent results demonstrate that selection of the appropriate donor locus likely occurs through mating-type and heterochromatin-dependent spreading of a protein complex that marks the correct donor locus.|Chromosomes/*genetics[MESH]|DNA-Binding Proteins/genetics/metabolism[MESH]|Gene Expression Regulation, Fungal/genetics[MESH]|Genes, Fungal[MESH]|Genes, Mating Type, Fungal[MESH]|Genes, Switch/*genetics[MESH]|Recombination, Genetic/genetics[MESH]|Reproduction, Asexual/*genetics[MESH]|Saccharomyces cerevisiae/*genetics/growth & development[MESH]|Schizosaccharomyces/*genetics/growth & development[MESH] |
