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The E2F family: specific functions and overlapping interests Attwooll C; Lazzerini Denchi E; Helin KEMBO J 2004[Dec]; 23 (24): 4709-16The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise. In this review, we summarise the most recent advances in the field and discuss the remaining key questions. In particular, we will focus on how specificity is achieved among the E2Fs.|*Gene Expression Regulation[MESH]|Animals[MESH]|Cell Cycle Proteins/classification/genetics/*metabolism[MESH]|Cell Cycle/*physiology[MESH]|Cell Proliferation[MESH]|DNA-Binding Proteins/classification/genetics/*metabolism[MESH]|E2F Transcription Factors[MESH]|Phenotype[MESH]|Protein Binding[MESH]|Transcription Factors/classification/genetics/*metabolism[MESH] |
