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lüll Qa-1 restriction of CD8+ suppressor T cells Sarantopoulos S; Lu L; Cantor HJ Clin Invest 2004[Nov]; 114 (9): 1218-21There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease.|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|CD4-Positive T-Lymphocytes/metabolism[MESH]|CD8-Positive T-Lymphocytes/*immunology/physiology[MESH]|HLA Antigens/metabolism[MESH]|HLA-E Antigens[MESH]|Histocompatibility Antigens Class I/metabolism/*physiology[MESH]|Humans[MESH]|Immune Tolerance[MESH]|Mice[MESH]|Models, Biological[MESH]|Peptides/chemistry[MESH]|Receptors, Interleukin-2/biosynthesis[MESH] |