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  • CD4+ Tregs and immune control
  • Fehervari Z; Sakaguchi S
  • J Clin Invest 2004[Nov]; 114 (9): 1209-17
  • Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.
  • |Animals[MESH]
  • |CD4-Positive T-Lymphocytes/*physiology[MESH]
  • |Forkhead Transcription Factors[MESH]
  • |Humans[MESH]
  • |Immune System/*physiology[MESH]
  • |Immune Tolerance[MESH]
  • |Ligands[MESH]
  • |Mice[MESH]
  • |Models, Biological[MESH]
  • |Phenotype[MESH]
  • |Receptors, Interleukin-2/biosynthesis[MESH]
  • |Repressor Proteins/metabolism[MESH]
  • |T-Lymphocytes, Regulatory/*physiology[MESH]
  • |Thymus Gland/metabolism/physiology[MESH]

  • *{{pmid15520849}}
    *<b>[ CD4+ Tregs and immune control ]</b> J Clin Invest 2004; 114(9) ; 1209-17 Fehervari Z; Sakaguchi S


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    J Clin Invest

    1209 9.114 2004