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Homocysteine: is it a clinically important cardiovascular risk factor?Lentz SR; Haynes WGCleve Clin J Med 2004[Sep]; 71 (9): 729-34Elevated plasma homocysteine is associated with an increased risk of myocardial infarction, stroke, and venous thromboembolism. Folic acid and other B vitamins lower plasma homocysteine levels, but whether this therapy confers a clinical benefit has yet to be determined. Until we know the results of ongoing clinical trials of homocysteine-lowering therapy, testing for and treating elevated homocysteine is probably justified only in patients with known cardiovascular disease or who are at high risk.|Cardiovascular Diseases/*blood/epidemiology[MESH]|Folic Acid/therapeutic use[MESH]|Homocysteine/*blood/metabolism[MESH]|Humans[MESH]|Hyperhomocysteinemia/epidemiology/etiology/physiopathology[MESH]|Myocardial Infarction/blood/epidemiology[MESH]|Reference Values[MESH]|Risk Factors[MESH]|Vitamin B Complex/therapeutic use[MESH] |
