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PDZ interactions and proximal tubular phosphate reabsorption Biber J; Gisler SM; Hernando N; Wagner CA; Murer HAm J Physiol Renal Physiol 2004[Nov]; 287 (5): F871-5In adults, the extent of renal reabsorption of P(i) and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-P(i) cotransporter NaPi-IIa (SLC34A1). Localization of this cotransporter is restricted to the apical membrane of proximal tubular cells, and its abundance is controlled by a number of factors and pathophysiological conditions. To guarantee a proper apical localization and specific regulated endocytosis of NaPi-IIa, an orchestrated pattern of protein interactions has to be envisaged. Attempts to screen for such interacting proteins resulted in the identification of a PDZ domain containing proteins. The purpose of this review is to discuss the roles of these PDZ proteins in proximal tubular Na-P(i) cotransport.|Animals[MESH]|Humans[MESH]|Kidney Tubules, Proximal/*metabolism[MESH]|Phosphates/*metabolism[MESH]|Sodium-Phosphate Cotransporter Proteins[MESH]|Sodium-Phosphate Cotransporter Proteins, Type IIa[MESH]|Symporters/metabolism[MESH] |
