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lüll The life cycle of C-myc: from synthesis to degradation Sears RCCell Cycle 2004[Sep]; 3 (9): 1133-7The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.|Animals[MESH]|Humans[MESH]|NIMA-Interacting Peptidylprolyl Isomerase[MESH]|Peptidylprolyl Isomerase/metabolism[MESH]|Phosphoprotein Phosphatases/metabolism[MESH]|Phosphorylation[MESH]|Proteasome Endopeptidase Complex/*metabolism[MESH]|Protein Transport/physiology[MESH]|Proto-Oncogene Proteins c-myc/*biosynthesis/*genetics[MESH]|Signal Transduction/*physiology[MESH]|Ubiquitin/*metabolism[MESH]|ras Proteins/metabolism[MESH] |