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lüll Enzymes of the L-arginine to nitric oxide pathway Stuehr DJJ Nutr 2004[Oct]; 134 (10 Suppl): 2748S-2751S; discussion 2765S-2767SL-Arginine is the biological precursor of nitric oxide (NO), which serves as an important signal and effector molecule in animals. This review summarizes some structure-function aspects of the mammalian nitric oxide synthases, which are enzymes that catalyze the oxidation of L-arginine to NO and L-citrulline. These include aspects related to: 1) the chemical transformations of L-arginine during enzyme catalysis, 2) binding of L-arginine or its structural analogs to the nitric oxide synthases, and 3) how L-arginine levels may affect product formation by the nitric oxide synthases and how this can be modulated by structural analogs of L-arginine.|Animals[MESH]|Arginine/*metabolism[MESH]|Citrulline/biosynthesis[MESH]|Humans[MESH]|Nitric Oxide Synthase/chemistry/*metabolism[MESH]|Nitric Oxide/biosynthesis/*metabolism[MESH]|Oxidation-Reduction[MESH]|Structure-Activity Relationship[MESH] |