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lüll Intravenous iloprost bridging to orthotopic liver transplantation in portopulmonary hypertension Minder S; Fischler M; Muellhaupt B; Zalunardo MP; Jenni R; Clavien PA; Speich REur Respir J 2004[Oct]; 24 (4): 703-7Portopulmonary hypertension (PPHTN) is associated with poor prognosis and high perioperative mortality after orthotopic liver transplantation. This study documents the first case of a patient with PPHTN who was successfully bridged to orthotopic liver transplantation with i.v. iloprost, a stable prostacyclin analogue. The PPHTN had resolved completely 4 months after successful transplantation. In conclusion, portopulmonary hypertension is a relative contraindication to orthotopic liver transplantation, which should be attempted only if pulmonary haemodynamics improve with prostanoids. In this context, iloprost may be a valuable alternative to epoprostenol.|*Liver Transplantation[MESH]|Alcoholism/complications[MESH]|Carcinoma, Hepatocellular/etiology/surgery[MESH]|Hepatitis C, Chronic/complications/surgery[MESH]|Humans[MESH]|Hypertension, Portal/*drug therapy/etiology/surgery[MESH]|Hypertension, Pulmonary/*drug therapy/etiology/surgery[MESH]|Iloprost/*administration & dosage[MESH]|Infusions, Intravenous[MESH]|Liver Cirrhosis/etiology/surgery[MESH]|Liver Neoplasms/etiology/surgery[MESH]|Middle Aged[MESH]|Preoperative Care[MESH]|Vasodilator Agents/*administration & dosage[MESH] |