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lüll Paxillin: adapting to change Brown MC; Turner CEPhysiol Rev 2004[Oct]; 84 (4): 1315-39Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.|Animals[MESH]|Cell Adhesion/physiology[MESH]|Cell Division/physiology[MESH]|Cell Movement/physiology[MESH]|Cytoskeletal Proteins/*chemistry/*physiology[MESH]|Extracellular Matrix/physiology[MESH]|Growth Substances/physiology[MESH]|Humans[MESH]|Integrins/physiology[MESH]|Paxillin[MESH]|Phosphoproteins/*chemistry/*physiology[MESH]|Signal Transduction/*physiology[MESH] |