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lüll Receptor editing in positive and negative selection of B lymphopoiesis Edry E; Melamed DJ Immunol 2004[Oct]; 173 (7): 4265-71In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and activation. Several positive and negative selection checkpoints to test this receptor have been described in B lymphopoiesis, aiming to ensure the generation of functionally competent, nonautoimmune repertoire. Secondary Ag receptor gene recombination allows B lymphocytes to replace an inappropriate receptor with a new receptor, a mechanism called receptor editing. This salvage mechanism uncouples the Ag receptor fate from that of the cell itself, suggesting that B cell repertoire is regulated by a process of receptor selection. Secondary rearrangements are stimulated in different stages of B cell development, where editing of the receptor is necessary to fulfill stage-specific requirements. In this study, we discuss the contribution of receptor editing in B lymphopoiesis and its regulation by positive and negative selection signals.|*Gene Rearrangement, B-Lymphocyte[MESH]|*Recombination, Genetic[MESH]|Animals[MESH]|B-Lymphocytes/*immunology/*metabolism[MESH]|Cell Differentiation/genetics/*immunology[MESH]|Humans[MESH]|Lymphopoiesis/genetics/*immunology[MESH]|Receptors, Antigen, B-Cell/*biosynthesis/physiology[MESH]|Signal Transduction/genetics/immunology[MESH] |